Development of a Microfluidic-Based Electrochemical Cell for Analyzing Bacterial Biofilms
The ubiquitous nature of biofilms has led to a growing need to be able to detect, control, and maintain or remove them. Therefore a robust testing platform that allows for multiple analytical techniques is required to better understand their multitude of properties. The development of the self-contained microfluidic-based electrochemical cell portion of a multifaceted analysis system is discussed in this paper. The integration of electrodes for electrical impedance spectroscopy(EIS) required that the reference and counter electrodes used in the EIS measurement remain free of bacteria to provide accurate measurements. This paper details the usage of COMSOL Multiphysics® software to determine the optimum geometry and flow conditions for maintaining the sterility of the reference and counter electrodes.
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