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Parameter Optimization for Finite-Element Method (FEM) based modeling of singlet oxygen during PDT

T. Zhu, and K. Wang
Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Publié en 2008

Photodynamic therapy(PDT) is a new cancer treatment modality using the photochemical reaction of a photosensitizing drug, light, and oxygen. The objective of this project is to determine the photochemical parameters necessary for singlet oxygen modeling during PDT using parameters obtained from a microscopic model.

FEM calculation in COMSOL Multiphysics was used to determine the model parameters for treatments with different fluence rates and fractionation treatments with different on/off time interval, respectively. The sensitivity of each model parameters to the necrosis depths and treatment conditions are examined.

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