Analyzing Drug Delivery and Osteoblast Growth on a Porous Scaffold in a Perfusion Bioreactor
Implantable Collagen sponges are used in Spinal Surgery as Drug Delivery Scaffolds. An optimal concentration of growth factor that strikes a balance between bone growth and adverse diffusion effects is difficult to find. The porous sponge also serves as a scaffold for Osteoblast growth, and fluid shear has been shown to mediate biological effects on that cell type.
We use COMSOL Multiphysics to model an in-vitro perfusion bioreactor system that contains a porous scaffold in the reaction chamber. The reaction engineering interface is used to model release of scaffold-bound growth factor, while its subsequent convection and diffusion are modeled as species transport in porous media. The Brinkman Equations are used to simulate fluid flow through the Porous phase.
![](/paper/image/10729/big.png)
Téléchargement
- sun_presentation.pdf - 0.72MB
- sun_paper.pdf - 0.28MB
- 18hracs.avi - 0.15MB